Neurobiology of Disease Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing

Davide Rivolta,1,2,3 Nazareth P. Castellanos,4 Cerisa Stawowsky,5 Saskia Helbling,6 Michael Wibral,5 Christine Grützner,1 Dagmar Koethe,7,8,9 Katharina Birkner,1,2 Laura Kranaster,7,8 Frank Enning,8 Wolf Singer,1,2,10 F. Markus Leweke,7,8* and Peter J. Uhlhaas1,2,11* 1Department of Neurophysiology, Max Planck Institute for Brain Research and 2Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main 60528, Germany, 3School of Psychology, University of East London, London E15 4LZ, United Kingdom, 4Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Politécnica de Madrid, Madrid 28223, Spain, 5MEG Unit, Brain Imaging Centre, Johann Wolfgang Goethe University, Frankfurt am Main 60529, Germany, 6Institute for Medical Psychology, Johann Wolfgang Goethe University, Frankfurt am Main 60054, Germany, 7Department of Psychiatry and Psychotherapy, University of Cologne, Cologne 50924, Germany, 8Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany, 9Department of General Psychiatry, Medical Faculty Heidelberg, Heidelberg University, Heidelberg 69115, Germany, 10Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, Frankfurt am Main 60438, Germany, and 11Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB, United Kingdom